A scalable, portable, FPGA-based implementation of the Unscented Kalman Filter

Sustained technological progress has come to a point where robotic/autonomous systems may well soon become ubiquitous. In order for these systems to actually be useful, an increase in autonomous capability is necessary for aerospace, as well as other, applications. Greater aerospace autonomous capability means there is a need for high performance state estimation. However, the desire to reduce costs through simplified development processes and compact form factors can limit performance. A hardware-based approach, such as using a Field Programmable Gate Array (FPGA), is common when high performance is required, but hardware approaches tend to have a more complicated development process when compared to traditional software approaches; greater development complexity, in turn, results in higher costs. Leveraging the advantages of both hardware-based and software-based approaches, a hardware/software (HW/SW) codesign of the Unscented Kalman Filter (UKF), based on an FPGA, is presented. The UKF is split into an application-specific part, implemented in software to retain portability, and a non-application-specific part, implemented in hardware as a parameterisable IP core to increase performance. The codesign is split into three versions (Serial, Parallel and Pipeline) to provide flexibility when choosing the balance between resources and performance, allowing system designers to simplify the development process. Simulation results demonstrating two possible implementations of the design, a nanosatellite application and a Simultaneous Localisation and Mapping (SLAM) application, are presented. These results validate the performance of the HW/SW UKF and demonstrate its portability, particularly in small aerospace systems. Implementation (synthesis, timing, power) details for a variety of situations are presented and analysed to demonstrate how the HW/SW codesign can be scaled for any application

A Scalable, FPGA-Based Implementation of the Unscented Kalman Filter

Autonomous aerospace systems may well soon become ubiquitous pending an increase in autonomous capability. Greater autonomous capability means there is a need for high-performance state estimation. However, the desire to reduce costs through simplified development processes and compact form factors can limit performance. A hardware-based approach, such as using a field-programmable gate array (FPGA), is common when high performance is required, but hardware approaches tend to have a more complicated development process when compared to traditional software approaches; greater development complexity, in turn, results in higher costs. Leveraging the advantages of both hardware-based and software-based approaches, a hardware/software (HW/SW) codesign of the unscented Kalman filter (UKF), based on an FPGA, is presented. The UKF is split into an application-specific part, implemented in software to simplify the development process, and a non-application-specific part, implemented in hardware as a parameterisable ‘black box’ module (i.e. IP core) to increase performance. Simulation results demonstrating a possible nanosatellite application of the design are presented; implementation (synthesis, timing, power) details are also presented

Protein Kinase C α Is a Central Signaling Node and Therapeutic Target for Breast Cancer Stem Cells

The epithelial-mesenchymal transition program becomes activated during malignant progression and can enrich for cancer stem cells (CSCs). We report that inhibition of protein kinase C α (PKCα) specifically targets CSCs but has little effect on non-CSCs. The formation of CSCs from non-stem cells involves a shift from EGFR to PDGFR signaling and results in the PKCα-dependent activation of FRA1. We identified an AP-1 molecular switch in which c-FOS and FRA1 are preferentially utilized in non-CSCs and CSCs, respectively. PKCα and FRA1 expression is associated with the aggressive triple-negative breast cancers, and the depletion of FRA1 results in a mesenchymal-epithelial transition. Hence, identifying molecular features that shift between cell states can be exploited to target signaling components critical to CSCs.National Cancer Institute (U.S.) (Grant P01-CA080111)National Institutes of Health (U.S.) (Grant R01-CA078461

BHPR research: qualitative1. Complex reasoning determines patients' perception of outcome following foot surgery in rheumatoid arhtritis

Background: Foot surgery is common in patients with RA but research into surgical outcomes is limited and conceptually flawed as current outcome measures lack face validity: to date no one has asked patients what is important to them. This study aimed to determine which factors are important to patients when evaluating the success of foot surgery in RA Methods: Semi structured interviews of RA patients who had undergone foot surgery were conducted and transcribed verbatim. Thematic analysis of interviews was conducted to explore issues that were important to patients. Results: 11 RA patients (9 ♂, mean age 59, dis dur = 22yrs, mean of 3 yrs post op) with mixed experiences of foot surgery were interviewed. Patients interpreted outcome in respect to a multitude of factors, frequently positive change in one aspect contrasted with negative opinions about another. Overall, four major themes emerged. Function: Functional ability & participation in valued activities were very important to patients. Walking ability was a key concern but patients interpreted levels of activity in light of other aspects of their disease, reflecting on change in functional ability more than overall level. Positive feelings of improved mobility were often moderated by negative self perception ("I mean, I still walk like a waddling duck”). Appearance: Appearance was important to almost all patients but perhaps the most complex theme of all. Physical appearance, foot shape, and footwear were closely interlinked, yet patients saw these as distinct separate concepts. Patients need to legitimize these feelings was clear and they frequently entered into a defensive repertoire ("it's not cosmetic surgery; it's something that's more important than that, you know?”). Clinician opinion: Surgeons' post operative evaluation of the procedure was very influential. The impact of this appraisal continued to affect patients' lasting impression irrespective of how the outcome compared to their initial goals ("when he'd done it ... he said that hasn't worked as good as he'd wanted to ... but the pain has gone”). Pain: Whilst pain was important to almost all patients, it appeared to be less important than the other themes. Pain was predominately raised when it influenced other themes, such as function; many still felt the need to legitimize their foot pain in order for health professionals to take it seriously ("in the end I went to my GP because it had happened a few times and I went to an orthopaedic surgeon who was quite dismissive of it, it was like what are you complaining about”). Conclusions: Patients interpret the outcome of foot surgery using a multitude of interrelated factors, particularly functional ability, appearance and surgeons' appraisal of the procedure. While pain was often noted, this appeared less important than other factors in the overall outcome of the surgery. Future research into foot surgery should incorporate the complexity of how patients determine their outcome Disclosure statement: All authors have declared no conflicts of interes

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

The Science Performance of JWST as Characterized in Commissioning

This paper characterizes the actual science performance of the James Webb Space Telescope (JWST), as determined from the six month commissioning period. We summarize the performance of the spacecraft, telescope, science instruments, and ground system, with an emphasis on differences from pre-launch expectations. Commissioning has made clear that JWST is fully capable of achieving the discoveries for which it was built. Moreover, almost across the board, the science performance of JWST is better than expected; in most cases, JWST will go deeper faster than expected. The telescope and instrument suite have demonstrated the sensitivity, stability, image quality, and spectral range that are necessary to transform our understanding of the cosmos through observations spanning from near-earth asteroids to the most distant galaxies.Comment: 5th version as accepted to PASP; 31 pages, 18 figures; https://iopscience.iop.org/article/10.1088/1538-3873/acb29